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Does Cathepsin S mediate fibroblast trans-differentiation and contribute to left ventricular remodelling after myocardial infarction?
Does Cathepsin S mediate fibroblast trans-differentiation and contribute to left ventricular remodelling after myocardial infarction?
Cathepsin S regulates scar formation and preserves left ventricular function after experimental myocardial infarction through TGF-β1 signaling and myofibroblast trans-differentiation.
Along with its established activities in ECM degradation, CatS plays novel roles in TGF-β1 signalling, myofibroblast trans-differentiation, and ECM protein synthesis, thereby regulating scar formation in the infarcted myocardium and preserving LV function after experimental MI.
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Chen et al. (2013) studied this question.
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