Does Cathepsin S mediate fibroblast trans-differentiation and contribute to left ventricular remodelling after myocardial infarction?
Cathepsin S regulates scar formation and preserves left ventricular function after experimental myocardial infarction through TGF-β1 signaling and myofibroblast trans-differentiation.
Along with its established activities in ECM degradation, CatS plays novel roles in TGF-β1 signalling, myofibroblast trans-differentiation, and ECM protein synthesis, thereby regulating scar formation in the infarcted myocardium and preserving LV function after experimental MI.
Chen et al. (Fri,) studied this question.