Why the study?
Can parameters of flow through paravalvular leak channels be reliably assessed using computational fluid dynamics simulations and related to hemolysis risk?
Can parameters of flow through paravalvular leak channels be reliably assessed using computational fluid dynamics simulations and related to hemolysis risk?
Computational fluid dynamics simulations can reliably assess flow parameters in paravalvular leaks, which correlate with hemolysis risk markers like LDH.
PVL flow assessment via simplified CFD is feasible; leaves open validation for clinical hemolysis risk stratification.
Parameters that describe blood flow through PVL channels can be reliably assessed in a simplified model. LDH levels in subjects with PVLs may be related to V₃₀₀ and Vt₃₀₀. Length and location of PVL channels may contribute to a risk of hemolysis in mitral PVLs.
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Kozłowski et al. (2022) studied this question.
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