Why the study?
Current practices such as corticosteroids for specific forms of myocarditis rely on anecdotal evidence, and randomized clinical trials of optimal therapeutic interventions are needed.
Highlights the lack of randomized clinical trial evidence for optimal therapeutic interventions, such as corticosteroids, in acute myocarditis.
Corticosteroids lack RCT support in acute myocarditis; leaves optimal immunosuppression unresolved pending trials.
Acute myocarditis affects approximately 4 to 14 per 100 000 people per year. First-line therapy depends on acuity, severity, clinical presentation, and etiology and includes supportive care. While corticosteroids are often used for specific forms of myocarditis (eg, eosinophilic or giant cell infiltrations), this practice is based on anecdotal evidence, and randomized clinical trials of optimal therapeutic interventions for acute myocarditis are needed.
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Ammirati et al. (2023) studied this question.
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