Does a favorable lifestyle reduce the risk of coronary artery disease in participants at high genetic risk?
Adherence to a healthy lifestyle is associated with a substantially reduced risk of coronary artery disease, even among individuals with a high genetic risk.
Across four studies involving 55,685 participants, genetic and lifestyle factors were independently associated with susceptibility to coronary artery disease. Among participants at high genetic risk, a favorable lifestyle was associated with a nearly 50% lower relative risk of coronary artery disease than was an unfavorable lifestyle. (Funded by the National Institutes of Health and others.).
Khera et al. (Sun,) studied this question.