Why the study?
Does a favorable lifestyle reduce the risk of coronary artery disease in participants at high genetic risk?
Population
55,685 participants across four studies assessed for genetic risk and lifestyle factors
Comparison
Favorable lifestyle vs Unfavorable lifestyle
Design
Cohort
Authors
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Supports lifestyle counseling in high genetic risk; leaves open causal confirmation by trials.
Does a favorable lifestyle reduce the risk of coronary artery disease in participants at high genetic risk?
Adherence to a healthy lifestyle is associated with a substantially reduced risk of coronary artery disease, even among individuals with a high genetic risk.
Khera et al. (2016) studied this question.
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