Demonstrates that diverse forms of pulmonary hypertension share signaling defects across angiopoietin-1, TIE2, and BMP receptors, highlighting potential therapeutic targets.
These findings suggest that all forms of pulmonary hypertension are linked by defects in the signaling pathway involving angiopoietin-1, TIE2, BMPR1A, and BMPR2 and consequently identify specific molecular targets for therapeutic intervention.
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Du et al. (2003) studied this question.
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