November 5, 2008Open Access

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

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Abstract

We suggest that delta-cell SST exerts a tonic inhibitory influence on insulin and glucagon secretion, which may facilitate the islet response to cholinergic activation. In addition, delta-cell SST is implicated in the nutrient-induced suppression of glucagon secretion.

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Hauge-Evans et al. (Wed,) studied this question.

synapsesocial.com/papers/69d5b88867f65a2d1d1f2c84 https://doi.org/https://doi.org/10.2337/db08-0792

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2Modulation of pancreatic somatostatin by adrenergic and cholinergic agonism and by hyper- and hypoglycemic sulfonamides1978 · 65 citations
3Textbook of Diabetes1991 · 574 citations
4Selective effect of some somatostatin analogs on glucagon as opposed to insulin release in rats in vivo1980 · 14 citations
5MIN6 β-cell–β-cell interactions influence insulin secretory responses to nutrients and non-nutrients2006 · 89 citations

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