Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients

Celestino Sardu; Nunzia D’Onofrio; Carlo Fumagalli; Maria Luisa Balestrieri; Alessandro Landolfi; C. La Marca; Valerio Giordano; Isabella Donisi; Pietro Rambaldi; Gianluca Gatta; Salvatore Cappabianca; Ferdinando Carlo Sasso; Michelangela Barbieri; Giuseppe Paolisso; Raffaele Marfella

doi:10.1016/j.jacadv.2026.102708

April 4, 2026JACC AdvancesOpen Access

Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients

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Key Points

This research investigates how vericiguat affects mitochondrial function and clinical outcomes in patients who do not respond to cardiac resynchronization therapy (CRT).
Evaluated the effects of vericiguat in a small cohort of CRT nonresponders.
Measured mitochondrial function and levels of inflammatory/oxidative stress.
Assessed CRT response after one year of treatment.
Vericiguat increased CRT response in the cohort at one year.
Improved mitochondrial function observed, likely contributing to the response.
Reduced levels of inflammatory and oxidative stress were noted.

Implication

Cohort study observes improved CRT response in CRT nonresponders, suggesting potential clinical benefits of vericiguat.

Abstract

In this small cohort of CRT nonresponders, vericiguat increased CRT response at 1 year, likely through improved mitochondrial function and reduced inflammatory/oxidative stress. Larger studies are needed to confirm these findings.

Discussion

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Cite This Study

Sardu et al. (2026) studied this question.

synapsesocial.com/papers/69d5efd374eaea4b11a795e4 https://doi.org/10.1016/j.jacadv.2026.102708

View Full Paper

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Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients

Key Points

Implication

Abstract

Discussion

Cite This Study

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