Investigation of the solution-phase structure of macrocyclic anti-leukemia drug midostaurin

Key Points

• To investigate the solution-phase structure of midostaurin, an anti-leukemia drug.
• Analysis of the electronic circular dichroism (ECD) spectrum in solution.
• Comparison of experimental ECD data with theoretical predictions.
• The experimental ECD spectrum showed excellent agreement with theoretical models.
• Suggests a well-defined solution structure for midostaurin.