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This case aims to showcase the effects of intravitreal methotrexate on subretinal proliferation bands in retinal detachment.

April 8, 2026Retinal Cases & Brief Reports0 citationsOpen Access

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Regression of a Subretinal Proliferation Band with Intravitreal Methotrexate in Recurrent Retinal Detachment: A Case Report

AAAnas AlkhabazStanford University JWJoseph WaiguruMorehouse School of Medicine LGLucie Y. GuoStanford University

Key Points

This case aims to showcase the effects of intravitreal methotrexate on subretinal proliferation bands in retinal detachment.
Case report of a patient with recurrent retinal detachment.
Intravitreal injections of methotrexate administered.
Observation of band regression post-treatment.
Notable regression of the subretinal band after treatment.
Methotrexate demonstrated anti-inflammatory and anti-proliferative effects.
Improvement in surgical challenges related to proliferative vitreoretinopathy.

Abstract

This case highlights subretinal band regression following intravitreal methotrexate injections in a patient with recurrent RRD. Methotrexate's anti-inflammatory and anti-proliferative properties may offer a beneficial effect in mitigating subretinal proliferative vitreoretinopathy, which can be surgically challenging.

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Regression of a Subretinal Proliferation Band with Intravitreal Methotrexate in Recurrent Retinal Detachment: A Case Report

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