What question did this study set out to answer?

This research aims to investigate the relationship between the Tpeak-Tend interval and short-term mortality in stroke patients.

April 8, 2026Medicina0 citationsOpen Access

New Marker of Brain–Heart Interaction: Tpeak–Tend Interval

NANazire Belgin AkilliKonya Eğitim ve Araştırma Hastanesi HMHüseyin MutluAksaray University ZDZerrin Defne DündarNecmettin Erbakan University

Key Result

The Tpeak-Tend interval in lead V2 is prolonged at admission in stroke patients and independently predicts in-hospital mortality (HR 0.96, 95% CI 0.93-0.99).

Key Points

This research aims to investigate the relationship between the Tpeak-Tend interval and short-term mortality in stroke patients.
Included individuals over 18 with ischemic or hemorrhagic stroke
Recorded demographic, laboratory, and imaging data
Obtained ECGs at hospital admission and 24 hours later
Followed patients for in-hospital mortality
89% had ischemic stroke while 17.6% had hemorrhagic stroke
Tpeak-Tend intervals were significantly longer at admission compared to 24 hours later (p = 0.003 for Tp-eV2 and p = 0.000 for Tp-eV5)
Tp-eV2 identified as an independent predictor of mortality (HR: 0.96, p = 0.008)

Structured PICO

Does the Tpeak-Tend interval on admission ECG predict in-hospital mortality in patients with stroke?

Population

108 adults (over 18 years of age) presenting with hemorrhagic or ischemic stroke (82.4% ischemic, 17.6% hemorrhagic)

Intervention

Measurement of Tpeak-Tend interval on ECG at hospital admission

Outcome

In-hospital mortalityhard clinical

Prolongation of the Tpeak-Tend interval in lead V2 at admission is an independent predictor of short-term in-hospital mortality in stroke patients.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Background and Objectives: The interaction between the brain and heart has become more interesting in the last 20 years. The most common cardiac complications after stroke are myocardial infarction, heart failure, arrhythmias, electrocardiographic disturbances, repolarization disorders, and sudden cardiac death. The prolonged Tpeak–Tend interval is an indicator of the electrical heterogeneity of the myocardium (abnormal repolarization) that causes malignant arrhythmias. We aimed to investigate whether the Tpeak–Tend interval, which reflects the heterogeneity of repolarization, is prolonged in stroke and its relationship with short-term mortality. Materials and Methods: Individuals over the age of 18 who presented with hemorrhagic or ischemic stroke were included in the study. Demographic characteristics, laboratory and imaging findings of the patients were recorded. ECGs were obtained at the time of admission to the hospital and 24 h later. Patients were followed for in-hospital mortality. Results: 89 (82.4%) of the patients had ischemic stroke, 19 (17.6%) had hemorrhagic stroke. It was determined that Tp-eV2 and Tp-eV5 at hospital admission were significantly longer than the 24th hour values. A total of 92.01 (16.3) ms at Tp-eV2 admission, 84.1 (16.3) ms after 24 h (p = 0.003), 91.9 (7.3) msTp-eV5 at admission, and 81.6 (17.8) ms (p = 0.000) after 24 h. In multivariate logistic regression analysis of in-hospital mortality, Tp-eV2 (HR: 0.96 (95% CI 0.93–0.99) p = 0.008) was determined as an independent predictor among cardiovascular parameters. Conclusions: Tp-e intervals were prolonged in both leads V2 and V5 in patients with stroke. Prolongation of lead V2 in the Tp-e interval is an independent indicator of short-term mortality among cardiovascular parameters.

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