Physical and cardiorespiratory fitness variables correlated positively with cardiovascular regulation complexity in healthy controls (r=0.354-0.548, p≤0.047) but not in men with T2DM.
Cross-Sectional (n=68)
Does the relationship between physical and cardiorespiratory fitness and cardiovascular regulation complexity differ in men with type 2 diabetes mellitus compared to healthy controls?
Type 2 diabetes mellitus appears to blunt the normal positive relationship between cardiorespiratory fitness and cardiovascular regulation complexity seen in healthy individuals.
Effect estimate: r = 0.354 to 0.548
p-value: p=0.001 ≤ p ≤ 0.047
Background/Objectives: Cardiovascular regulation complexity (CRC) is an underexplored health marker in the context of type 2 diabetes mellitus (T2DM). Additionally, associating CRC with physical and cardiorespiratory fitness variables could provide greater insight into how physical conditioning impacts cardiovascular health in the context of T2DM. This study aims to investigate whether the relationship between physical and cardiorespiratory fitness and CRC differs according to the presence or absence of T2DM. Methods: Sixty-eight men were equally divided into the T2DM group (T2DMG; 57 ± 6 years old and 28.4 ± 3.1 kg/m2) and the control group (CG; 52 ± 5 years old and 25.1 ± 2.8 kg/m2). Participants underwent a resting cardiovascular data collection and a cardiopulmonary exercise test on a cycle ergometer. For each group, the relative peak power (W/kgPEAK) and peak oxygen consumption (VO2PEAK) were correlated with the CRC indices, namely, Shannon entropy, the complexity index, the normalized complexity index, and the sample entropy from heart period (HP) and systolic arterial pressure (SAP) series. A partial correlation was performed for each group, controlling for age, physical activity level, and metabolic cart. Results: Only the CG showed positive and significant correlations between relative VO2PEAK and W/kgPEAK and CRC indices derived from the HP series (0.354 ≤ r ≤ 0.548 and 0.001 ≤ p ≤ 0.047). Correlations with the SAP series were not significant, regardless of the groups. Conclusions: In this sample, there was no positive relationship between physical and cardiorespiratory fitness variables and CRC indices among individuals with T2DM. Further large sample studies are needed to elucidate the factors involved in T2DM that impact CRC.
Signini et al. (Fri,) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=68). Physical and cardiorespiratory fitness vs. Control group (men without T2DM) was evaluated on Correlation between physical/cardiorespiratory fitness and cardiovascular regulation complexity (CRC) indices (r = 0.354 to 0.548, p=0.001 ≤ p ≤ 0.047). Physical and cardiorespiratory fitness variables correlated positively with cardiovascular regulation complexity in healthy controls (r=0.354-0.548, p≤0.047) but not in men with T2DM.