Immunogenicity and Safety of Live Attenuated Varicella Vaccine in Children and Youth With Solid Organ Transplants in Canada: A Canadian Immunization Research Network Study

Key Points

• The aim is to evaluate the immunogenicity and safety of the live attenuated varicella vaccine in children post-solid organ transplantation.
• Assessed the immunogenic response to the varicella vaccine in children and youth with solid organ transplants
• Evaluated safety and tolerability of the vaccine administration
• Monitored VZV serostatus and clinical outcomes post-vaccination
• Live attenuated varicella vaccine was shown to be immunogenic in the cohort
• The vaccine was generally well tolerated with minimal adverse effects
• Recommendation for vaccine consideration in seronegative children with appropriate follow-up