A clinical examination identifies SERPINA12 mutations causing skin thickening in a child, suggesting genetic factors.
A 3-year-old girl presented to our dermatology clinic with a 2-year history of pruritic, symmetric skin thickening and erythema involving the palms and soles, extending to the dorsal surfaces ([Figure 1][1]). She had had mild flexural eczema since infancy; however, her persistent palmoplantar
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Pan et al. (2026) studied this question.
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