Comparative evaluation reveals the Leader assay is more reliable for evaluating somatic hypermutation in chronic lymphocytic leukemia, suggesting its primary use.
These findings indicate that the Leader assay provides a more reliable assessment of SHM status, with higher concordance with SS. Although the FR1 assay may offer additional information regarding clonal patterns, its results should be interpreted cautiously. Given the limited sample size, further studies are warranted to validate these findings. Overall, the Leader assay appears to be more suitable as a primary tool for SHM evaluation, with FR1 results serving a complementary role when interpreted in clinical context.
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Kang et al. (2026) studied this question.
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