‘Comparative study between the use of topical glyceryl trinitrate versus topical calcium channel blocker (diltiazem) in treatment of chronic anal fissure’
Prospective trial compares healing effects of topical glyceryl trinitrate and diltiazem in chronic anal fissures, indicating differential efficacy and side effects.
Key Points
The aim is to compare the effectiveness of topical diltiazem and glyceryl trinitrate in treating chronic anal fissures.
Conducted a prospective randomized clinical trial with 80 participants aged 18–60 years
Divided participants into two groups: one received 2% diltiazem and the other 0.2% glyceryl trinitrate
Measured healing rates, recurrence, and side effects over a follow-up period
At 6 weeks, complete healing occurred in 80% of the diltiazem group and 75% of the glyceryl trinitrate group
Recurrence rates were 10% for diltiazem and 12.5% for glyceryl trinitrate at 24 weeks
Side effects were more common in the glyceryl trinitrate group, with headaches reported in 67.5% of patients