RNA sequencing of left ventricular tissue from a mouse model of hypertrophic cardiomyopathy identified 35 differentially expressed long non-coding RNA genes compared to non-transgenic controls.
Does a transgenic TNNT2 ∆160E mouse model of hypertrophic cardiomyopathy exhibit differential expression of long non-coding RNAs compared to non-transgenic controls?
This preclinical study identified 35 differentially expressed long non-coding RNAs in a mouse model of hypertrophic cardiomyopathy, providing a transcriptomic dataset for future mechanistic and translational research.
p-value: p=<0.05
Long non-coding RNAs (lncRNAs) are transcripts that do not typically code for protein but have essential roles in the regulation of transcription and translation in health and disease. Hypertrophic cardiomyopathy (HCM) is a commonly inherited cardiovascular disease. While a number of studies have described transcriptional regulation in human heart tissue and animal models of HCM, whether lncRNA plays a role in the pathophysiology of HCM remains unknown. We present an RNA-Seq dataset on left ventricle samples from transgenic HCM TNNT2 ∆160 mice (n = 31) and non-transgenic (n = 33) mice (n = 64 total) in which differentially expressed lncRNAs are delineated. We determined the mouse lncRNA genes that have a human ortholog, which may be useful for future investigators aiming to study the role of particular lncRNAs in human HCM.
Branscom et al. (Mon,) conducted a other in Hypertrophic cardiomyopathy (n=64). Transgenic TNNT2 ∆160 mutation vs. Non-transgenic (nTG) mice was evaluated on Differentially expressed lncRNA genes (p=<0.05). RNA sequencing of left ventricular tissue from a mouse model of hypertrophic cardiomyopathy identified 35 differentially expressed long non-coding RNA genes compared to non-transgenic controls.