What question did this study set out to answer?

This case aims to explore familial complex regional pain syndrome (CRPS) in pediatric siblings and its implications for diagnosis and treatment.

April 8, 2026Journal of Medical Case Reports0 citationsOpen Access

Familial complex regional pain syndrome in pediatric siblings: a diagnostic challenge and therapeutic success—a case report

FAFaten Ahmad Al-Kateb DDDuaa Dyab RARola Alsalamah

Key Points

This case aims to explore familial complex regional pain syndrome (CRPS) in pediatric siblings and its implications for diagnosis and treatment.
Case report of pediatric siblings with familial CRPS
Systematic differential diagnosis approach undertaken
Early aggressive treatment included Gabapentin and intravenous immunoglobulin (IVIG)
Demonstrated familial occurrence of CRPS in pediatric siblings
Highlighted effectiveness of early treatment with Gabapentin and IVIG
Emphasized the role of environmental and genetic factors in CRPS pathogenesis

Abstract

This represents the first reported case of familial CRPS in pediatric siblings, demonstrating the complex interplay between environmental triggers and genetic susceptibility in CRPS pathogenesis. The case highlights the importance of systematic differential diagnosis in pediatric extremity pain and demonstrates the efficacy of early aggressive treatment with Gabapentin and IVIG in pediatric CRPS (Mangnus et al. in Drugs 82(5):511531, 2022; Goebel et al. in Ann Intern Med 152(3):152-158, 2010).

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