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This research investigates the role of catecholamines in muscle loss, particularly focusing on older men and reduced muscle mass.

April 8, 2026Open Access

Muscle Loss Driven by Extracellular Signal-Regulated Kinase Suppression via β-Adrenergic Activation in High-Normal Catecholamine Status

JLJieun LeeChungnam National University JKJu Yeon KwakChungnam National University HLHo Yeop LeeChungnam National University

Key Points

This research investigates the role of catecholamines in muscle loss, particularly focusing on older men and reduced muscle mass.
Monitored catecholamine levels in different populations
Analyzed the relationship between catecholamines and muscle mass
Assessed β-adrenergic activation effects on muscle preservation
Catecholamine levels correlate with muscle and fat mass
Suppression of extracellular signal-regulated kinase linked to higher muscle loss
Indicates potential for targeted treatment in individuals with elevated catecholamines

Abstract

Catecholamine levels are associated with age, sex, muscle mass, and fat mass. Monitoring catecholamine levels, particularly in older men and in individuals with reduced muscle mass, may help manage age-related muscle loss and lead to individualized treatment strategies.

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