What question did this study set out to answer?

The research aims to determine the relationship between baseline serum PINP levels and lumbar spine bone mineral density (BMD) response to teriparatide treatment.

April 8, 2026Open Access

Baseline serum PINP is associated with early lumbar spine bone mineral density gains during twice-weekly teriparatide treatment: the OASIS cohort study

RNRui Niimi TKTomonori KobayakawaObayashi (Japan)YEYuki EtaniThe University of Osaka

Key Points

The research aims to determine the relationship between baseline serum PINP levels and lumbar spine bone mineral density (BMD) response to teriparatide treatment.
Analyzed serum PINP levels in participants at baseline.
Measured lumbar spine bone mineral density (BMD) before and during treatment.
Examined the association between serum PINP and BMD gains during treatment.
Baseline serum PINP is an independent predictor for early gains in lumbar spine BMD.
Participants with higher PINP levels showed significantly better BMD response to teriparatide treatment.

Abstract

Baseline serum PINP represents one of the clinically relevant independent predictors of early LS BMD response to twice-weekly teriparatide.

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