Why the study?
Does PCC therapy improve mortality and morbidity in patients with warfarin-associated intracranial hemorrhage?
Does PCC therapy improve mortality and morbidity in patients with warfarin-associated intracranial hemorrhage?
Rapid INR correction with PCC therapy alone is insufficient to significantly improve the poor prognosis (high mortality and morbidity) of warfarin-associated intracranial hemorrhage.
Rapid INR correction with PCC alone does not reduce mortality or morbidity in warfarin-ICH; leaves open whether adjunctive strategies improve prognosis.
PCC therapy rapidly corrected international normalized ratio in the majority of patients, yet mortality and morbidity rates remained high. Rapid international normalized ratio correction alone may not be sufficient to alter prognosis after aaICH.
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Dowlatshahi et al. (2012) studied this question.