What question did this study set out to answer?

To assess connectivity alterations involving the posterior cingulate cortex and hippocampus across the whole brain and between each other in patients with mild cognitive impairment and early Alzheimer's disease.

June 25, 2008Alzheimer s & Dementia

Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment

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To assess connectivity alterations involving the posterior cingulate cortex and hippocampus across the whole brain and between each other in patients with mild cognitive impairment and early Alzheimer's disease.
Evaluated brain connectivity patterns using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI).
Analyzed connections between the posterior cingulate cortex, hippocampus, and the rest of the brain across patient cohorts with mild cognitive impairment and Alzheimer's disease.
Connectivity from both the posterior cingulate cortex and hippocampus to the whole brain was significantly decreased in mild cognitive impairment and Alzheimer's disease.
Connectivity specifically linking the posterior cingulate cortex to the hippocampus showed a marked reduction, indicating potential utility as an early imaging biomarker.

Implication

Neuroimaging study reveals reduced posterior cingulate and hippocampal connectivity in mild cognitive impairment and Alzheimer's disease, suggesting an early imaging biomarker.

Abstract

The fMRI and DTI results confirmed decreased connectivity from both the PCC and hippocampus to the whole brain in MCI and AD and reduction in connectivity between these two regions, which plausibly represents an early imaging biomarker for AD.

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Cite This Study

Zhou et al. (2008) studied this question.

synapsesocial.com/papers/69d6ab60e328128020aa7f04 https://doi.org/10.1016/j.jalz.2008.04.006

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Implication

Neuroimaging study reveals reduced posterior cingulate and hippocampal connectivity in mild cognitive impairment and Alzheimer's disease, suggesting an early imaging biomarker.

Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment

Key Points

Implication

Abstract

Discussion

Cite This Study

Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment

Key Points

Implication

Abstract

Discussion

Cite This Study

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