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Clinical study reveals cerebral energy disturbances align closer with low blood flow than low oxygen delivery in subarachnoid hemorrhage, suggesting therapies raising flow preserve metabolism.
While MD is a feasible tool to study cerebral energy metabolism, its validity is limited to a focal area around the MD catheter. Cerebral energy disturbances were more related to low CBF than to low CDO 2 . Considering the high rate of mitochondrial dysfunction, treatments that increase CBF but not CDO 2 , such as hemodilution, may still benefit glucose delivery to drive anaerobic metabolism.
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Wettervik et al. (2022) studied this question.
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