What question did this study set out to answer?

To determine how treatment delay, patient age, and baseline stroke severity alter the therapeutic efficacy and safety of intravenous alteplase in acute ischaemic stroke.

August 5, 2014ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

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To determine how treatment delay, patient age, and baseline stroke severity alter the therapeutic efficacy and safety of intravenous alteplase in acute ischaemic stroke.
Individual patient data meta-analysis pooling participant-level records from randomised controlled trials comparing intravenous alteplase against control.
Analyzed clinical outcomes stratified by time from stroke onset to treatment, baseline stroke severity, and age groups.
Earlier administration of intravenous alteplase yields substantially greater functional recovery, with therapeutic benefit diminishing steadily as treatment delay increases.
Net clinical benefits of alteplase extend across a wide spectrum of patient ages and initial stroke severity levels when administered promptly.

Implication

Randomized trial meta-analysis reveals how treatment delay, age, and stroke severity modulate alteplase efficacy in acute ischaemic stroke, highlighting the critical value of rapid intervention.

Abstract

UK Medical Research Council, British Heart Foundation, University of Glasgow, University of Edinburgh.

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Cite This Study

Emberson et al. (2014) studied this question.

synapsesocial.com/papers/69d6bcf7e328128020aa8287 https://doi.org/10.1016/s0140-6736(14)60584-5

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Implication

Randomized trial meta-analysis reveals how treatment delay, age, and stroke severity modulate alteplase efficacy in acute ischaemic stroke, highlighting the critical value of rapid intervention.

Abstract

UK Medical Research Council, British Heart Foundation, University of Glasgow, University of Edinburgh.

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

Key Points

Implication

Abstract

Discussion

Cite This Study

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

Key Points

Implication

Abstract

Discussion

Cite This Study

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