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A comparative study of alcoholized and phenolized T.A.B. vaccines has been made. 2. No difference could be detected in the immunological potency of the two vaccines. 3. The contentions of Felix and others that the reactions with alcoholized vaccine are less severe and ‘Vi’ response greater than with phenolized vaccine are confirmed. 4. The change over of large scale production in the Sudan from phenolized to alcoholized vaccine is not considered justifiable. I wish to record my grateful thanks to Dr E. S. Horgan, Assistant Director Research, Sudan Medical Service, for the help and advice given in the carrying out of these experiments and preparation of this paper and also to Col. H. T. Findlay for his helpful criticism and permission to quote the conclusions of his preliminary experiments.
A. Drysdale (Wed,) studied this question.