Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses

Lawrence R. Soma; Cornelius E. Uboh; Yowen You; Fuyu Guan; Raymond C. Boston

doi:10.2460/ajvr.72.9.1234

September 1, 2011American Journal of Veterinary ResearchOpen Access

Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses

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Key Points

To characterize the pharmacokinetics of triamcinolone acetonide and assess its suppressive effects on endogenous plasma hydrocortisone and cortisone levels across three routes of administration in horses.
Administered triamcinolone acetonide to horses via intravenous (i.v.), intra-articular (i.a.), and intramuscular (i.m.) routes.
Profiled drug pharmacokinetics and quantified resulting alterations in circulating endogenous hydrocortisone concentrations.
Characterized distinct pharmacokinetic profiles of triamcinolone acetonide following intravenous, intra-articular, and intramuscular administration.
Observed profound suppression of endogenous hydrocortisone secretion following a single dose of triamcinolone acetonide across all routes.

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Implication

Pharmacokinetic study reveals profound suppression of endogenous hydrocortisone following triamcinolone acetonide administration in horses, highlighting substantial systemic endocrine effects.

Abstract

Pharmacokinetics of TA and related changes in hydrocortisone were described following i.v., i.a., and i.m. administration. A single administration of TA has profound effects on secretion of endogenous hydrocortisone.

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Soma et al. (2011) studied this question.

synapsesocial.com/papers/69d6c0f51a315865a9ab32df https://doi.org/10.2460/ajvr.72.9.1234

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Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses

Key Points

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Implication

Abstract

Discussion

Cite This Study

Pharmacokinetics of intra-articular, intravenous, and intramuscular administration of triamcinolone acetonide and its effect on endogenous plasma hydrocortisone and cortisone concentrations in horses

Key Points

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Implication

Abstract

Discussion

Cite This Study

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