Why the study?
Do intravenous midazolam, diazepam, and lorazepam affect autonomic neurocardiac regulation in humans?
Do intravenous midazolam, diazepam, and lorazepam affect autonomic neurocardiac regulation in humans?
Intravenous benzodiazepines exert a biphasic effect on autonomic neurocardiac regulation by initially reducing vagal tone and subsequently depressing the cardiac pacemaker, effects that are reversible with flumazenil.
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May confound autonomic monitoring during sedation; hypothesis-generating for flumazenil reversal in critical care.
Agelink et al. (2002) studied this question.
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