Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Key Points

To assess the utility of serum bile acid levels as a prognostic biomarker in infants with biliary atresia who achieve normal bilirubin concentrations after Kasai portoenterostomy.
Evaluated postoperative circulating serum bile acid concentrations in infants with biliary atresia.
Tracked prognostic outcomes specifically within the subgroup of patients who achieved normalized bilirubin levels following Kasai portoenterostomy.
Postoperative serum bile acid concentrations correlate with clinical prognosis in infants despite the normalization of bilirubin.
Circulating bile acids provide predictive utility for assessing ongoing hepatic risk after successful surgical biliary drainage.

Clinical study demonstrates serum bile acid prognostic value in infants after Kasai portoenterostomy, indicating improved risk stratification.

Serum bile acid levels may be a useful prognostic biomarker for infants achieving normalized bilirubin levels after KP.

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Harpavat et al. (2022) studied this question.

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