Why the study?
Does Pitx2 deficiency lead to myocardial fat deposition and impaired mitochondrial function following myocardial infarction in neonatal mice?
Does Pitx2 deficiency lead to myocardial fat deposition and impaired mitochondrial function following myocardial infarction in neonatal mice?
Pitx2 plays a crucial role in maintaining proper cardiac cellular composition and mitochondrial function during neonatal heart regeneration, preventing pathological myocardial fat deposition after injury.
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Pitx2-Cox7c axis may influence neonatal post-MI adiposity and mitochondria; hypothesis-generating for regeneration, with no clinical translation yet.
Li et al. (2018) studied this question.
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