⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

May 10, 2021Journal of Clinical Oncology

Phase II Study of Maintenance Rucaparib in Patients With Platinum-Sensitive Advanced Pancreatic Cancer and a Pathogenic Germline or Somatic Variant in BRCA1, BRCA2, or PALB2

Kim A. Reiss Rosemarie Mick Mark H. O’Hara Ursina Teitelbaum Thomas B. Karasic Charles Schneider Stacy Cowden Traci Southwell Janae Romeo Natallia Izgur Zain M. Hannan Rashmi Tondon Katherine L. Nathanson Robert H. Vonderheide Max M. Wattenberg Gregory L. Beatty Susan M. Domchek

View at Publisher

Ask AI

Bookmark

Share

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Abstract

Maintenance rucaparib is a safe and effective therapy for platinum-sensitive, advanced PC with a PV in BRCA1, BRCA2, or PALB2. The finding of efficacy in patients with gPALB2 and sBRCA2 PVs expands the population likely to benefit from PARPi beyond gBRCA1/2 PV carriers.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Reiss et al. (2021) studied this question.

synapsesocial.com/papers/69d70f295413bc3de5ab3510 https://doi.org/10.1200/jco.21.00003

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 10 related papers. Consider them for comparative context:

1Image-Based Consensus Molecular Subtyping Refines Prognostication in Stage II/III Colorectal Cancer: A Retrospective Analysis of the SCOT TrialJournal of Clinical Oncology · 2026
2Per- and Polyfluoroalkyl Substance Exposure and Breast Cancer Incidence in the Sister StudyJournal of Clinical Oncology · 2026
3International Initiative on a Refined Staging System for Medullary Thyroid Cancer: A Multinational Multicenter StudyJournal of Clinical Oncology · 2026
4Circulating Tumor DNA Profiling Across Phase II/III Ewing Sarcoma Trials Identifies High-Risk Patients With TP53 , STAG2 , and CDKN2A AlterationsJournal of Clinical Oncology · 2026
5Feasibility and Tolerability of Chemoimmunotherapy Given During Induction for Treatment of Patients With High-Risk Neuroblastoma: A Report From the Children's Oncology GroupJournal of Clinical Oncology · 2026
6Stereotactic Ablative Radiotherapy Versus Surgical Resection for Early-Stage Non–Small Lung Cancer: An Emulated Target TrialJournal of Clinical Oncology · 2026
7Immunochemotherapy for Borderline Resectable or Locally Advanced Pancreatic Cancer: A Randomized Controlled TrialJournal of Clinical Oncology · 2026
8Methylphenidate for Hematologic Cancer–Related Fatigue: A Randomized Clinical TrialJournal of Clinical Oncology · 2026
9Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.4Journal of Clinical Oncology · 2026
10KEYNOTE-867: A Phase III, Randomized, Double-Blind Study of Stereotactic Body Radiotherapy With Pembrolizumab for Unresected Stage I or II Non–Small Cell Lung CancerJournal of Clinical Oncology · 2026

More from Journal of Clinical Oncology

More from University of Pennsylvania