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February 14, 2013DiabetologiaOpen Access

Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin

Shun‐ichiro Asahara Yuki Shibutani Kyoko Teruyama Hiroyuki Inoue Yukina Kawada Hiroaki Etoh Tomokazu Matsuda Maki Kimura-Koyanagi N. Hashimoto Mizuho Sakahara Wakako Fujimoto Harumi Takahashi Shuji Ueda Tetsuya Hosooka Takaya Satoh Hiroshi Inoue Michihiro Matsumoto Atsu Aiba Masato Kasuga Yoshiaki Kido

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Abstract

In RAC1-deficient pancreatic beta cells, F-actin acts as a barrier for insulin granules and reduces glucose-stimulated insulin secretion.

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Cite This Study

Asahara et al. (2013) studied this question.

synapsesocial.com/papers/69d71a913f906f6a06bef079 https://doi.org/10.1007/s00125-013-2849-5

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