Key result
Pulmonary hypertension impairs systolic RCA flow proportional to RV pressure, reducing total myocardial perfusion.
Why the study?
Right coronary artery flow characteristics in patients with pulmonary hypertension and their relation to right ventricular pressure and mass were not well described.
How is right coronary artery flow altered in patients with pulmonary hypertension compared to controls?
How is right coronary artery flow altered in patients with pulmonary hypertension compared to controls?
Pulmonary hypertension causes systolic flow impediment in the right coronary artery, which is proportional to RV pressure and mass, leading to reduced total mean flow in severe RV hypertrophy.
Answers are grounded in this paper and cite their sources.
Reduced RCA flow in severe PH RV hypertrophy may signal ischemia risk; hypothesis-generating for perfusion-targeted studies.
Although in controls, RCA flow is similar in systole and diastole, in PH there is systolic flow impediment, which is proportional to RV pressure and mass. In patients with severe RV hypertrophy total mean flow is reduced.
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Wolferen et al. (2007) studied this question. Pulmonary hypertension causes right coronary artery systolic flow impediment proportional to RV pressure and mass, reducing total mean flow in severe RV hypertrophy.
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