Make it strained and fluorinated! A rhodium-catalyzed domino diazotization/cyclopropenation reaction involving trifluoroethylamine hydrochloride and alkynes has been developed for the synthesis of trifluoromethyl cyclopropenes that can be easily functionalized to afford useful CF3-containing building blocks for drug discovery.
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Morandi et al. (2010) studied this question.
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