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Synapse
January 31, 1995Proceedings of the National Academy of Sciences247 citationsOpen Access

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

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Why the study?

Does thrombomodulin deficiency affect embryonic survival and development in mice?

Population

Mice and embryos with targeted thrombomodulin gene deficiency and wild-type littermates

Comparison

Targeted disruption of the murine thrombomodulin… vs Wild-type (TM+/+) littermates

Design

Preclinical

Follow-up

Up to embryonic day 9.5 in vivo

Authors

AHAileen M. HealyHRHelen RayburnRRRobert Rosenberg

Discussion

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Overview

TM essential for murine embryogenesis; leaves open relevance to human pregnancy loss or therapeutic targeting.

Structured PICO

Does thrombomodulin deficiency affect embryonic survival and development in mice?

P
Population
Mice and embryos with targeted thrombomodulin (TM) gene deficiency (heterozygous TM+/- and homozygous TM-/-) and wild-type (TM+/+) littermates
I
Intervention
Targeted disruption of the murine thrombomodulin (TM) gene
C
Comparator
Wild-type (TM+/+) littermates
O
Outcome
Embryonic survival and development

Thrombomodulin is essential for normal embryonic development in utero, as its absence causes embryonic lethality before the development of a functional cardiovascular system.

Cite This Study

Healy et al. (1995) studied this question.

synapsesocial.com/papers/69d722eda98988943d563812https://doi.org/10.1073/pnas.92.3.850
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