In situ biosynthetic BC/zeolite hybrid hemostat for quick clot

This is the authors' abstract. We don't add key points for this paper.

Zeolite‐based hemostatic agents are considered as an outstanding material to achieve rapid and definitive hemostasis in pre‐hospital management. However, developing a safer zeolitic hemostat that avoids the potential thrombotic risk caused by tiny zeolite residue in bleeding wounds remains a critical challenge. In this research, we employ an in situ biosynthesis process to fabricate a sandwich‐like structured bacterial cellulose/zeolite (BC/zeolite) hybrid hemostat. Zeolite particles were firmly bonded into the BC membranes with <1% leaching after 24 soaking. This hemostat displays effective hemostatic performance after calcium ion‐exchange process. The BC/zeolite‐Ca hemostat can significantly decrease in vitro blood clotting time from 7.5 ± 0.3 min to 2.2 ± 0.3 min. This work achieves a low‐cost, eco‐friendly, and low‐risk approach through in situ biosynthesis in the preparation of BC‐ and zeolite‐based hybrid for pre‐hospital hemostasis applications.