Demographic and phenotypic features of 70 families segregating Barrett’s oesophagus and oesophageal adenocarcinoma

This is the largest series of families with BO/OAC yet reported, features of which are consistent with inherited germline predisposition. Further, the SIR of cancers other than OAC/OGJAC was 0.71 among 70 probands, indicating these individuals were not more likely to develop non-OAC cancers.