Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Key Points

• To quantify the global, regional, and national burden, prevalence, mortality, and disability-adjusted life years (DALYs) attributable to Alzheimer's disease and other dementias between 1990 and 2016.
• Conducted a systematic analysis using data and standardized modeling methods from the Global Burden of Disease Study 2016.
• Estimated prevalence, incidence, mortality, years of life lost, years lived with disability, and DALYs across 195 countries and territories from 1990 to 2016.
• Global cases and overall burden of Alzheimer's disease and other dementias increased substantially from 1990 to 2016, primarily driven by population growth and aging demographics.
• Substantial heterogeneity in age-standardized prevalence and burden metrics was observed across geographic regions and socioeconomic development tiers.