October 17, 2008SHILAP Revista de lepidopterologíaOpen Access

Foot-and-Mouth Disease Virus Persists in the Light Zone of Germinal Centres

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Population

Naïve cattle

Design

Preclinical

Authors

NJNicholas JuleffThe Pirbright Institute MWMiriam WindsorThe Pirbright Institute ERElizabeth ReidUniversity of Nottingham

Discussion

Member takes

Implication

May explain FMDV persistence and durable immunity in cattle; leaves open relevance to vaccines or other hosts.

Structured PICO

Population

Naïve cattle

Intervention

Primary infection with Foot-and-Mouth Disease Virus (FMDV)

Outcome

Localization and maintenance of FMDV in the light zone of germinal centres

Maintenance of non-replicating FMDV in the light zone of germinal centres represents a source of persisting infectious virus and contributes to long-lasting antibody responses.

Cite This Study

Juleff et al. (2008) studied this question.

synapsesocial.com/papers/69d72a24b815ed77c2bef0c0 https://doi.org/10.1371/journal.pone.0003434

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Foot-and-Mouth Disease Virus Persists in the Light Zone of Germinal Centres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Foot-and-Mouth Disease Virus Persists in the Light Zone of Germinal Centres

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider