Altered functional connectivity of the primary somatosensory cortex during evoked pain is associated with clinical and autonomic dysfunction in fibromyalgia.
Our study demonstrates that both somatic and nonsomatic dysfunction in FM, including clinical pain, pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are closely linked with the degree to which evoked deep tissue pain alters S1 connectivity to salience/affective pain-processing regions. Additionally, diminished connectivity between S1 subregions during the rest phase in FM may result from ongoing widespread clinical pain.
Kim et al. (Mon,) studied this question.