October 1, 1999Avian PathologyOpen Access

Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes

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Why the study?

Does sequential administration of heterologous live-attenuated infectious bronchitis vaccines (Ma5 followed by 4/91) improve respiratory tract protection against heterologous IB serotypes in chickens?

Population

Specified pathogen free chickens

Comparison

Infectious bronchitis Ma5 vaccine administered… vs Revaccination with a vaccine of the same…

Design

Preclinical

Follow-up

Up to 5 weeks of age

Authors

JCJane K. A. CookInstitute of Economic Research of the Slovak Academy of Sciences SOS. J. OrbellInstitution of Engineering and Technology MWM. A. WoodsInstitution of Engineering and Technology

Discussion

Member takes

Implication

May broaden cross-protection against IB serotypes in poultry; leaves open field validation and optimal schedules.

Structured PICO

Population

Specified pathogen free chickens

Intervention

Infectious bronchitis (IB) Ma5 vaccine (Massachusetts serotype) administered at 1 day old followed by the heterologous 4/91 vaccine at 2 weeks of age

Comparator

Revaccination with a vaccine of the same serotype as the first vaccine, or Ma5 vaccine given at the same time as or following the 4/91 vaccine

Outcome

Protection of the respiratory tract, measured by assessing ciliary activity of the tracheal epithelium following challenge at 5 weeks of age with IB strains of many serotypessurrogate

Sequential vaccination with heterologous live-attenuated infectious bronchitis vaccines broadens protection against multiple IB serotypes in chickens without needing new serotype-specific vaccines.

Cite This Study

Cook et al. (1999) studied this question.

synapsesocial.com/papers/69d72b24cd480cb7e5f50f2b https://doi.org/10.1080/03079459994506

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Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider