Why the study?
Does specific inhibition of P4-H improve cardiac function after acute myocardial infarction in rats?
Does specific inhibition of P4-H improve cardiac function after acute myocardial infarction in rats?
Inhibition of P4-H improves cardiac function after myocardial infarction in rats, likely through the stabilization of hypoxia-inducible factor rather than modulation of collagen metabolism.
Should not change practice; hypothesis-generating for P4-H inhibition in post-MI remodeling.
Specific inhibition of the P4-H improved cardiac function without affecting the infarct size after experimental myocardial infarction in rats. Stabilization of HIF rather than inhibition of collagen maturation by P4-HI may prevent cardiac remodeling after MI.
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Philipp et al. (2006) studied this question.
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