Why the study?
Does myostatin directly regulate muscle fibroblasts and extracellular matrix production in skeletal muscle?
Population
Muscle fibroblasts (in vitro and in vivo models of skeletal muscle fibrosis)
Design
Preclinical
Authors
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May support myostatin inhibition to limit muscle fibrosis; leaves open clinical translation from animal data.
Does myostatin directly regulate muscle fibroblasts and extracellular matrix production in skeletal muscle?
Myostatin directly stimulates muscle fibroblast proliferation and extracellular matrix production, identifying it as a potential target for anti-fibrotic therapies in chronic myopathies.
Li et al. (2008) studied this question.
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