Thiazolidinediones, Metformin, and Outcomes in Older Patients With Diabetes and Heart Failure
Why the study?
Do thiazolidinediones and metformin reduce mortality in older patients with diabetes and heart failure?
Population
older patients with diabetes and heart failure
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports safety of thiazolidinediones and metformin in older diabetic HF patients; leaves open confirmation by randomized trials.
Structured PICO
Do thiazolidinediones and metformin reduce mortality in older patients with diabetes and heart failure?
P
Population
older patients with diabetes and heart failure
I
Intervention
thiazolidinediones and metformin
O
Outcome
mortalityhard clinical
Thiazolidinediones and metformin may be safe and potentially beneficial in older patients with concurrent diabetes and heart failure, though randomized trials are needed to confirm.
Limitations
- observational design
Cite This Study
Masoudi et al. (2005) studied this question.