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January 20, 2015Arthritis & Rheumatology

Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis

Adam P. Cribbs Alan Kennedy Henry Penn Parisa Amjadi Patricia Green Jordan E. Read Fionula M. Brennan Bernard Gregory Richard Williams

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Abstract

This study identifies a novel mechanism of action of MTX, in which treatment of RA patients with MTX restores defective Treg cell function through demethylation of the FOXP3 locus, leading to a subsequent increase in FoxP3 and CTLA-4 expression.

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Cribbs et al. (2015) studied this question.

synapsesocial.com/papers/69d74c8fb1cb92dd1bb8a586 https://doi.org/10.1002/art.39031

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1DNA Modification Mechanisms and Gene Activity During DevelopmentOriginal Research · 1975 · 1,974 citations
2DNA methylation controls <i>Foxp3</i> gene expressionIn Vitro Study · 2008 · 785 citations
3Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα TherapyOriginal Research · 2004 · 1,254 citations
4Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritisOriginal Research · 2008 · 303 citations
5CD4+CD25+ regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluidIn Vitro Study · 2004 · 531 citations

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