What question did this study set out to answer?

To evaluate how the timing and specific type of menopause relate to the incidence of cardiovascular disease in women across multiple international cohorts.

May 29, 2020Human ReproductionOpen Access

Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: pooled analysis of individual data from 10 international studies

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To evaluate how the timing and specific type of menopause relate to the incidence of cardiovascular disease in women across multiple international cohorts.
Conducted a pooled individual participant data analysis using data harmonized from 10 international observational studies through the InterLACE consortium.
Tracked incident cardiovascular disease events according to reported age at menopause onset and menopausal type (natural versus surgical).
Variations in incident cardiovascular disease risk correspond closely with both the specific age at onset and whether menopause occurred naturally or surgically.
Earlier onset of menopause across cohorts associates with heightened subsequent risks of incident cardiovascular events.

Implication

Pooled analysis uncovers variations in incident cardiovascular disease risk by menopausal age and type across international cohorts, indicating differential midlife vascular vulnerability.

Abstract

InterLACE project is funded by the Australian National Health and Medical Research Council project grant (APP1027196). GDM is supported by Australian National Health and Medical Research Council Principal Research Fellowship (APP1121844). There are no competing interests.

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Cite This Study

Zhu et al. (2020) studied this question.

synapsesocial.com/papers/69d74e89df21310ab048f4de https://doi.org/10.1093/humrep/deaa124

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Implication

Pooled analysis uncovers variations in incident cardiovascular disease risk by menopausal age and type across international cohorts, indicating differential midlife vascular vulnerability.

Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: pooled analysis of individual data from 10 international studies

Key Points

Implication

Abstract

Discussion

Cite This Study

Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: pooled analysis of individual data from 10 international studies

Key Points

Implication

Abstract

Discussion

Cite This Study

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