June 1, 2015Open Access
GLP-1 reduces metalloproteinase-9 induced by both hyperglycemia and hypoglycemia in type 1 diabetes. The possible role of oxidative stress
Structured PICO
Does GLP-1 infusion reduce oxidative stress and MMP-9 levels during acute hyperglycemia and hypoglycemia in type 1 diabetes?
P
Population
Patients with type 1 diabetes
I
Intervention
Simultaneous infusion of GLP-1 during acute hyperglycemia and hypoglycemia
C
Comparator
Acute hyperglycemia and hypoglycemia without GLP-1 infusion
O
Outcome
Plasma levels of MMP-9 and 8-iso-PGF2αsurrogate
GLP-1 may counteract oxidative stress and MMP-9 activation induced by acute glycemic excursions in type 1 diabetes.
Abstract
Dear editor MMP-9 has been involved in favoring cardiovascular disease, and evidence suggests that oxidative stress favors its release. Previous studies demonstrated that during both acute hyperglycemia and hypoglycemia an oxidative stress is produced in type 1 diabetes. On the other hand, GLP-1 has shown an antioxidant power. In this study an acute hyperglycemia and hypoglycemia, with or without the simultaneous infusion of GLP-1, were produced. During both hyperglycemia and hypoglycemia, an acute increase of MMP-9 and 8-iso-PGF2α plasma levels was observed. GLP-1 significantly reduced this increase. This study suggests that metalloproteinase-9 is activated by acute hyperglycemia and hypoglycemia because they generate an oxidative stress and that GLP-1 counteracts this effect.