Why the study?
Is aripiprazole effective and safe compared to placebo, haloperidol, or risperidone in patients with schizophrenia or acute mania?
Population
Patients with acute schizophrenic relapse, chronic schizophrenia, and acute mania
Comparison
Aripiprazole 15-30 mg once-daily vs Placebo, haloperidol 7-10 mg/day, and…
Design
Review
Authors
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Aripiprazole may be considered for schizophrenia; leaves open need for updated head-to-head safety trials in mania.
Is aripiprazole effective and safe compared to placebo, haloperidol, or risperidone in patients with schizophrenia or acute mania?
Aripiprazole is an effective atypical antipsychotic for schizophrenia and acute mania with a favorable safety profile, particularly regarding weight gain and cardiac rhythm.
David Taylor (2003) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: