January 23, 2021Journal of Biochemical and Molecular Toxicology

Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis

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Why the study?

The potential mechanisms and signaling pathways underlying the prophylactic effect of proanthocyanidin extract against doxorubicin-induced cardiotoxicity required investigation.

Does proanthocyanidin extract prevent doxorubicin-induced cardiotoxicity in a rat model?

Structured PICO

Does proanthocyanidin extract prevent doxorubicin-induced cardiotoxicity in a rat model?

Population

32 male albino rats

Intervention

Proanthocyanidin extract (PE) 50 mg/kg bw/once daily orally for 4 weeks simultaneously with doxorubicin

Comparator

Doxorubicin alone (10 mg/kg intraperitoneally on Days 3, 9, 15, and 21)

Outcome

Serum heart damage biomarkers and cardiac tissue histopathologysurrogate

Proanthocyanidin extract shows potential as a preventative agent against doxorubicin-induced cardiotoxicity in a preclinical rat model by modulating oxidative stress, inflammation, and fibrogenesis.

Discussion

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Implication

Does not change practice; leaves open whether proanthocyanidin prevents doxorubicin cardiotoxicity in humans.

Cite This Study

Sadek et al. (2021) studied this question.

synapsesocial.com/papers/69d75bf0f44a16d01ef307c1 https://doi.org/10.1002/jbt.22716

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Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis

Structured PICO

Discussion

Implication

Cite This Study

Proanthocyanidin alleviates doxorubicin‐induced cardiac injury by inhibiting NF‐kB pathway and modulating oxidative stress, cell cycle, and fibrogenesis

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider