May 20, 2019Open Access

Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study

PICO estructurado

Does higher BMI and fat mass index increase the risk of aortic valve stenosis and other cardiovascular conditions in UK Biobank participants?

Población

Participants in the UK Biobank

Intervención

Higher body mass index (BMI) and fat mass index (genetic exposure)

Comparador

Lower body mass index (BMI) and fat mass index

Resultado

Risk of 14 cardiovascular conditions, including aortic valve stenosishard clinical

Genetic evidence supports a causal association between higher BMI/fat mass index and an increased risk of aortic valve stenosis and other cardiovascular conditions.

Resumen

This study provides evidence that higher BMI and particularly fat mass index are associated with increased risk of aortic valve stenosis and most other cardiovascular conditions.

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Cite This Study

Larsson et al. (Mon,) studied this question.

synapsesocial.com/papers/69d75d70b4cef8fedc48f945 https://doi.org/https://doi.org/10.1093/eurheartj/ehz388

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