The motor phenotype of Parkinson's disease in relation to age at onset

Key Points

• To determine how age at symptom onset influences the motor phenotype and overall clinical presentation of Parkinson's disease.
• Assessed clinical features and motor symptom profiles across patient cohorts stratified by early-onset and late-onset Parkinson's disease.
• Demonstrated marked clinical differences in motor presentation and symptom expression between early-onset and late-onset cohorts.
• Identified distinct phenotypic patterns with direct implications for optimizing diagnostic workflows and individualized therapeutic management.