Why the study?
Does a plasma multibiomarker panel reflecting extracellular matrix fibrillar collagen homeostasis identify the presence of left ventricular hypertrophy and diastolic heart failure?
Does a plasma multibiomarker panel reflecting extracellular matrix fibrillar collagen homeostasis identify the presence of left ventricular hypertrophy and diastolic heart failure?
A plasma multibiomarker panel reflecting collagen homeostasis may serve as a useful diagnostic tool for identifying structural remodeling and diastolic heart failure.
Hypothesis-generating for noninvasive LVH/DHF detection; requires prospective validation before clinical adoption.
Plasma biomarkers reflecting changes in extracellular matrix fibrillar collagen homeostasis, combined into a multibiomarker panel, have discriminative value in identifying the presence of structural remodeling (LVH) and clinical disease (DHF).
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Zile et al. (2011) studied this question.
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