February 25, 2011Open Access
View Full PaperPlasma Biomarkers That Reflect Determinants of Matrix Composition Identify the Presence of Left Ventricular Hypertrophy and Diastolic Heart Failure
Structured PICO
Does a plasma multibiomarker panel reflecting extracellular matrix fibrillar collagen homeostasis identify the presence of left ventricular hypertrophy and diastolic heart failure?
P
Population
Patients assessed for left ventricular hypertrophy (LVH) and diastolic heart failure (DHF)
I
Intervention
Plasma multibiomarker panel reflecting changes in extracellular matrix fibrillar collagen homeostasis
O
Outcome
Identification of the presence of structural remodeling (LVH) and clinical disease (DHF)surrogate
A plasma multibiomarker panel reflecting collagen homeostasis may serve as a useful diagnostic tool for identifying structural remodeling and diastolic heart failure.
Abstract
Plasma biomarkers reflecting changes in extracellular matrix fibrillar collagen homeostasis, combined into a multibiomarker panel, have discriminative value in identifying the presence of structural remodeling (LVH) and clinical disease (DHF).